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Wednesday 22 June 2016

Rheumatoid arthritis


Rheumatoid arthritis (RA) is a serious, painful, and chronic (long-lasting) disease. It is an autoimmune disease - a disease where the body's immune system attacks healthy cells. When a person has RA, their immune system attacks the joints and the tissues around the joints in the body. This causes different problems, like:
The capsules around the joints get swollen

The body makes too much synovial fluid (the special fluid that is supposed to cushion the joints)
Tough fibrous tissue builds up in the synovium area (which is also supposed to help cushion the joints)
Eventually, RA can destroy a person's articular cartilage. Normally, articular (having to do with the joints) cartilage covers the end of bones where they come together to form joints. This keeps the bones from rubbing against each other. If the articular cartilage has been destroyed by RA, the bones will rub against each other, which is very painful.

No one knows what causes RA, but some theories are that it has to do with hormones, environment, and genes. There is no cure, but doctors have determined ways to help slow down and reduce the impact of the disease. Women are two to three times more likely than men to get rheumatoid arthritis. Most cases of RA occur in people between the ages of 25 and 55

Treatment for Rheumatoid arthritis


There is no known cure for rheumatoid arthritis. To date, the goal of treatment in rheumatoid arthritis is to reduce joint inflammation and pain, maximize joint function, and prevent joint destruction and deformity. Early medical intervention has been shown to be important in improving outcomes. Aggressive management can improve function, stop damage to joints as monitored on X-rays, and prevent work disability. Optimal RA treatment involves a combination of medications, rest, joint-strengthening exercises, joint protection, and patient (and family) education. Treatment is customized according to many factors such as disease activity, types of joints involved, general health, age, and patient occupation. RA treatment is most successful when there is close cooperation between the doctor, patient, and family members.


The degree of destructiveness of rheumatoid arthritis varies among affected individuals. Those with uncommon, less destructive forms of the disease or disease that has quieted after many years of activity ("burned out" rheumatoid arthritis) can be managed with rest plus pain control and anti-inflammatory medications alone. In general, however, function is improved and disability and joint destruction are minimized when the condition is treated earlier with second-line drugs (disease-modifying antirheumatic drugs), even within months of the diagnosis. Most people require more aggressive second-line drugs, such as methotrexate, in addition to anti-inflammatory agents. Sometimes these second-line drugs are used in combination.

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